Hormonal changes during menopause

Published 11/06/2024 (16) views

Menopause generally occurs in three stages: perimenopause, menopause and postmenopause. Perimenopause is the period before menopause when hormone levels begin to fluctuate, causing a variety of symptoms. This period can last from several months to several years. Menopause is the period when menstruation finally stops, while postmenopause includes the period after menopause when hormone levels stabilize at a low level.

The average age at which women experience menopause is around 51, although this can vary greatly depending on individual factors such as genetics, lifestyle and health status. Some women may experience menopause earlier, as early as the age of forty, while others may experience menopause later, up to the age of fifty-five or even later. Early menopause, which can start before age 40, can be related to certain medical conditions or treatments, such as chemotherapy or oophorectomy. There are also factors that can delay menopause, such as some lifestyle factors and genetic components.

Changes in the level of estrogen, progesterone and other hormones. How do they affect a woman's body?

Changes in the levels of estrogen, progesterone, and other hormones that occur during menopause have a profound effect on a woman's body, causing a variety of physical and emotional symptoms.

ESTROGEN

During perimenopause, the ovaries begin to produce less estrogen and its levels become irregular. Fluctuations in estrogen levels can cause hot flashes, night sweats, vaginal dryness and sleep disturbances. These symptoms are due to the fact that estrogen plays an important role in thermoregulation, blood circulation and the health of the vaginal mucosa.

PROGESTERONE

Progesterone also plays an important role in regulating the menstrual cycle and maintaining pregnancy. A decrease in its levels can cause irregular bleeding, breast tenderness and mood swings. Because progesterone affects a brain chemical, low levels can affect a woman's emotional state, causing irritability, depression, or anxiety.

OTHER HORMONES

In addition to estrogen and progesterone, other hormones such as testosterone and follicle-stimulating hormone (FSH) also change during menopause. Although testosterone is more commonly associated with men, it is also important for women, especially for its role in maintaining muscle mass, bone density, and sex drive. During menopause, testosterone levels also decrease, which can lead to a lack of energy, decreased sex drive, and loss of muscle mass. Conversely, FSH levels increase as the body tries to stimulate the ovaries to produce more estrogen.

LONG-TERM EFFECTS ON HEALTH

Hormonal changes during menopause also have long-term effects on a woman's health. Decreased estrogen levels can contribute to bone loss and the development of osteoporosis, as estrogen is important for the process of bone regeneration. It also increases the risk of cardiovascular disease because estrogen has a protective effect on the heart and blood vessels.

The hormonal changes that occur during menopause have a wide-ranging effect on a woman's body, causing various symptoms and increasing the risk of certain health problems. Understanding these changes helps women better prepare for this stage of life and find appropriate ways to manage symptoms and maintain health.


Menopause symptoms

Menopause symptoms are varied and can vary greatly from woman to woman, but the most common symptoms include hot flashes, night sweats, vaginal dryness, trouble sleeping, mood swings, lack of energy and decreased sex drive. These symptoms are mainly caused by a decrease in estrogen and progesterone levels, as well as changes in the levels of other hormones such as testosterone and follicle-stimulating hormone (FSH).

  • Hot flashes and night sweats are among the most common symptoms of menopause. They occur due to thermoregulation disorders caused by a decrease in estrogen levels. Estrogen plays an important role in regulating body temperature, so its deficiency can cause sudden sensations of heat accompanied by sweating, usually starting in the face and upper body. These symptoms can be extremely unpleasant and interfere with daily life and quality of sleep.
  • Vaginal dryness is another common symptom of menopause caused by decreased estrogen production. Estrogen helps maintain the moisture and elasticity of the vaginal mucosa, so its deficiency can cause dryness, irritation and pain during intercourse. This can have a significant impact on a woman's sex life and overall quality of life.
  • Sleep disturbances, such as difficulty falling asleep or frequent awakenings during the night, are also common during menopause. They can be related to hot flashes and night sweats, as well as hormonal changes that affect the brain's chemical balance. Progesterone, which has a calming effect, also decreases, which can contribute to sleep disturbances.
  • Mood swings, irritability, depression and anxiety are other important symptoms of menopause, often related to hormonal imbalances. Estrogen and progesterone affect the activity of brain neurotransmitters such as serotonin and dopamine, so changes in their levels can affect emotional state. Hormonal changes can also cause a lack of energy, fatigue and decreased sex drive, as they affect a woman's overall physical and psychological state.

In summary, menopause symptoms are directly related to hormonal changes that occur due to a decrease in ovarian activity. Understanding the causes of these symptoms can help women better manage this life transition and seek appropriate treatment and support.

Long-term health problems related to hormonal changes are possible

The hormonal changes that occur during menopause can have long-term consequences for a woman's health, especially due to the drop in estrogen and progesterone levels. One of the most important long-term health concerns is the increased risk of osteoporosis. Estrogen plays an important role in bone regeneration, helping to maintain bone density and strength. When estrogen levels drop, bone resorption (wasting) begins to outpace bone formation, making bones brittle and at increased risk of fracture. This is especially important for older women, for whom bone fractures can cause serious health problems and reduce quality of life.

Another significant health concern associated with the hormonal changes of menopause is an increased risk of cardiovascular disease. Estrogen has a protective effect on the cardiovascular system because it helps regulate blood cholesterol levels by lowering "bad" cholesterol and increasing "good" cholesterol. In addition, estrogen promotes the elasticity of blood vessels and healthy circulation. A drop in estrogen levels during menopause increases the risk of blood vessel stiffness and arterial plaque build-up, which can lead to hypertension, atherosclerosis and ultimately heart attack or stroke.

Hormonal changes can also affect the body's metabolic processes, increasing the risk of metabolic syndrome, which includes high blood pressure, high blood sugar, excess abdominal fat, and abnormal cholesterol or triglyceride levels. These factors together increase the risk of heart disease, stroke and type 2 diabetes. A decrease in estrogen levels can affect the distribution of body fat, causing fat to accumulate in the abdominal area, which is more associated with heart disease.

In addition, hormonal changes can affect cognitive function and mood, increasing the risk of dementia and Alzheimer's disease. Estrogen has neuroprotective properties, protecting brain cells from degeneration and promoting cerebral blood flow. Its deficiency can lead to deterioration of cognitive function, memory disorders and increase the risk of Alzheimer's disease.

Finally, the hormonal changes of menopause can affect urinary tract and genital health. A decrease in estrogen levels can cause urinary tract atrophy, increasing the risk of urinary incontinence and urinary tract infections. Atrophy of the vaginal mucosa may also occur, causing vaginal dryness, irritation and pain during intercourse, which can affect sex life and overall quality of life.


In summary, the hormonal changes that occur during menopause can have many long-term health consequences, including bone, cardiovascular, metabolic, cognitive and urinary health. Understanding the impact of these changes can help women and their healthcare professionals take preventive measures and treatments to reduce the risk of long-term health problems and maintain a good quality of life.

Information sources

  1. "Menopause: Hormone Changes and Health Risks" - National Institute on Aging
  2. Menopause and Hormones - The North American Menopause Society (NAMS)
  3. "Hormonal Changes in Menopause" - Mayo Clinic
  4. "Menopause: Changes and Challenges" - Cleveland Clinic
  5. "Hormone Replacement Therapy and Its Effects" - Harvard Medical School
  6. "Estrogen and Progesterone in Menopause: Physiology and Symptoms" - Endocrine Society

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